Study Finds Cannabis Compounds Prevent Infection By Covid-19 Virus

Original article by A.J. Herrington on Forbes

Compounds in cannabis can prevent infection from the virus that causes Covid-19 by blocking its entry into cells, according to a study published this week by researchers affiliated with Oregon State University. A report on the research, “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants,” was published online on Monday by the Journal of Natural Products.

The researchers found that two cannabinoid acids commonly found in hemp varietals of cannabis, cannabigerolic acid, or CBGA, and cannabidiolic acid, also known as CBDA, can bind to the spike protein of SARS-CoV-2, the virus that causes Covid-19. By binding to the spike protein, the compounds can prevent the virus from entering cells and causing infection, potentially offering new avenues to prevent and treat the disease.

“Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2,” the researchers wrote in an abstract of the study.

The study was led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, in collaboration with scientists at the Oregon Health & Science University. Van Breeman said that the cannabinoids studied are common and readily available.

“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said, as quoted by local media. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans.”

Cannabinoids Effective Against New Variants

Van Breemen added that CBDA and CBGA blocked the action of emerging variants of the virus that causes Covid-19, saying that “our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

The spike protein is the same part of the virus target by Covid-19 vaccines and antibody therapies. In addition to the spike protein, SARS-CoV-2 has three more structural proteins as well as 16 nonstructural proteins and several compounds van Breemen characterized as “accessory” proteins, all of which are potential targets for drugs developed to prevent Covid-19.

“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” van Breeman said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”

Although further research is needed, van Breemen noted that study shows the cannabinoids could be developed into drugs to prevent or treat Covid-19.

“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen noted. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”

Van Breeman also noted that the research showed the cannabinoids were effective against new variants of the virus, which he said are “one of the primary concerns” in the pandemic for health officials and clinicians.

“These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen,” said van Breemen. “Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”

The researcher added that “resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2.”

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HAWAIIAN HAZE HEMP FLOWER

The Hawaiian Haze hemp strain is a bit of a mystery. The name suggests that the marijuana strain Hawaiian Haze was bred with a high-CBD hemp variety. Like the marijuana version of this genetic, Hawaiian Haze hemp has pronounced tropical flavors and powerful effects.

Pungent tropical fruity flavors are the hallmark of the Hawaiian Haze hemp flower. Its smell has a hint of pine and pepper, products of the plant’s terpenes such as myrcene and alpha-pinene.

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ELEKTRA HEMP FLOWER

Elektra was bred by crossing Early Resin Berry (ERB) and ACDC. The breeder, Oregon CBD, was able to create a very high CBD hemp strain (up to 21%) with less than 0.3% THC through this cross. The parent strain AC/DC is a popular high-CBD strain that can reach up to 19% CBD.

Elektra hemp flower has a strong pine scent with tropical citrus and earth flavors which come from the strain’s terpenes: myrcene, beta-caryophyllene, phytol, alpha-bisabolol, and guaiol are commonly detected Elektra terpenes.

Elektra’s other parent, ERB, is a bit of a mystery. What is known is that it also produces high levels of CBD. ERB has signature sweet berry flavors with hints of citrus. The Elektra hemp strain is likewise high in CBD and rich in flavor. Some users even detect pine and citrus flavors with a subtle spiciness of hops.

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What is CBD?

Cannabidiol (CBD) is the powerful, legal and natural derivative of the hemp and cannabis plant that is taking the world by storm and widely considered a “miracle supplement”. The cannabis plant contains about 85 cannabinoids, the chemical compounds responsible for the way marijuana effects users, with the two most widely discussed being CBD and THC. Cannabinoids play a vital role in the human body which has endocannabinoid receptors located throughout it. These receptors comprise what is known as our endocannabinoid systems and are stimulated (whether by external cannabinoids or the ones already within us), they work to maintain homeostasis.

While tetrahydrocannabinol (THC) is what’s responsible for cannabis’ psychoactive properties, cannabidiol (CBD) is non-psychoactive and, based on the current research available and user testimonials, offers an array of therapeutic benefits ranging from cancer prevention and treatment to pain relief.

The Potential Benefits of CBD

Based on currently available research CBD appears to be nothing short of miraculous – a great, natural alternative for pharmaceuticals used to treat a host of diseases. The following factoids were curated from the top cannabidiol studies:

  • CBD is a powerful anti-inflammatory and regulator of gastric motility, which makes it a potential therapy for IBS, Crohn’s disease, and colitis.
  • At high doses, CBD activates the 5-ht1A receptor which helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting.
  • CBD is a powerful antioxidant, which makes it a preventative of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. Its antioxidant properties also make it an age-reduction skin therapy.
  • CBD’s anti-inflammatory quality has been found to alleviate the symptoms of multiple sclerosis. Because of its antioxidant properties, it may also prevent multiple sclerosis and/or prevent the disease from escalating.
  • CBD is a positive allosteric modulator of the mu and delta opioid receptors. This means it enhances the ability of these receptors to receive endogenous enkephalins which can increase quality of life and naturally reduce chronic pain in patients with conditions ranging from fibromyalgia to arthritis to cancer.
  • CBD’s antipsychotic properties make it a viable alternative to pharmaceuticals for schizophrenic patients.
  • CBD activates PPAR-gamma receptors. PPAR-gamma receptors are located on the cell’s nuclei and play a role in lipid uptake, insulin sensitivity, dopamine release and the degradation of beta-amyloid plaque. This is why CBD has been found to have natural value for individuals with diabetes, schizophrenia, and Alzheimer’s disease.
  • CBD has been found to not only effectively treat insomnia, but to create stable sleep patterns and, consequently, long-term relief from sleeplessness.
  • CBD’s interaction with the endocannabinoid system helps to reduce nausea, particularly in chemo patients. Studies show that CBD actively destroys cancer cells, which makes it a potential non-toxic, painless alternative to chemotherapy.
  • CBD also antagonizes GPR55 receptors which are widely distributed in the brain and help to control bone density and blood pressure. When activated, GPR55 promotes cancer cell proliferation. This antagonizing action helps explain the natural value of supplementing with CBD in individuals with cancer, osteoporosis, and high blood pressure.
  • Perhaps one of the most exciting and well-known applications of CBD oil is its potential impact for adults and children with epilepsy. Individuals who were experiencing dozens of seizures daily have found that CBD can dramatically decrease these numbers and find near instant relief from attacks.



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What is CBD Isolate?

Hemp CBD isolate is cannabidiol in its purest form possible making it the most powerful form of CBD currently available.
CBD isolate is the extraction of CBD from the cannabis plant so that the subsequent product is pure. Unwanted plant material is removed from the extraction, leaving a concentrated CBD isolate, which amplifies the healing properties of the cannabinoid.

Consuming isolate (as opposed to smoking a high CBD strain of cannabis) yields one higher concentrations of CBD in smaller amounts, making it a great medicine for those who need it.

CBD Products Made from Hemp are 100% Legal

CBD products are produced one of two places, medical cannabis or industrial hemp plants. While still illegal under federal law, cannabis is legal in several states but because it has a low THC content (>.3%), industrial hemp does not fall under these same regulations. This allows consumers to purchase and use CBD as a natural supplement without worrying about any legal repercussions.

Many cannabis users who are solely interested in the medicinal value of marijuana find CBD isolate products to be extremely appealing and effective.

FDA Disclaimer

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions. All products on this site contain less than .02% THC.


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† The statements on this website have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
**All products sold on site contain less than .3% THC.
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